Type 2 Diabetes – Genes That Reveal Which Women Will Develop Gestational Diabetes

Certain genes make women worldwide susceptible to Type 2 and Gestational, or pregnancy-related, diabetes. Those genes can vary from one population to another. Scientists at the Madras Diabetes Research Foundation in Chennai, India, have found two genes that make Southern Indians susceptible to the condition. globalnews

This particular study was reported on in the journal Diabetes Technology and Therapeutics in February 2015 and included…


  • 518 women with Gestational diabetes and
  • 910 women who each had a healthy pregnancy.


Twelve variations of genes previously associated with the condition in other populations were measured. Two of them were associated with Gestational diabetes in Southern Indians. From the information gained it was concluded two variations of a gene called CDKAL1 were associated with diabetes that developed during pregnancy. finance

Although the above was the first study to look at the genetics of Gestational diabetes in Southern India, studies on other populations have been completed. In February of 2014 the journal Endocrinology and Gynecology reported on research from Trakya University in Turkey…


  • 44 women who were diagnosed with diabetes during their pregnancy, were compared genetically with
  • 50 women with a normal pregnancy.


It was found women with a gene called IRS-2 DD had almost three times the risk of Gestational diabetes as those with a gene known as GG. A gene with the name IRS-2 D gave women an 86 percent higher risk of developing Gestational diabetes than a gene called IRS-2 G. wilmslowdecorators

In April 2015 the European Journal of Obstetrics, Gynecology and Reproductive Biology will report the results of a study performed at the Obstetrics and Gynecology Hospital of Fudan University, in Shanghai, China. Researchers looked at genes known to be associated with Gestational diabetes, as well as other genes that could interact with them. Genes cause the cell to make certain proteins, so the scientists look at how the proteins made by various genes might react in the body. Based upon those interactions, six genes, called CYP1A1, LEPR, ESR1, GYS2, AGRP, and CACNA1G, were suspected of contributing to the development of diabetes during pregnancy. sarah-j

Undoubtedly the time will come when pregnant women or women planning their pregnancy, can be routinely tested for genes that predispose them to Gestational diabetes. Until that time, a family history of Type 2 diabetes can give some idea whether women are genetically susceptible to developing diabetes during their pregnancy. 123sporters

Every woman contemplating pregnancy should normalize her weight first, and continue to keep it normal throughout the pregnancy. Following a prescribed diet and exercise program will help prevent or control Gestational diabetes.

Although managing your disease can be very challenging, Type 2 diabetes is not a condition you must just live with. You can make simple changes to your daily routine and lower both your weight and your blood sugar levels. Hang in there, the longer you do it, the easier it gets.


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